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geeM - Solve Generalized Estimating Equations

GEE estimation of the parameters in mean structures with possible correlation between the outcomes. User-specified mean link and variance functions are allowed, along with observation weighting. The 'M' in the name 'geeM' is meant to emphasize the use of the Matrix package, which allows for an implementation based fully in R.

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5.09 score 3 stars 15 dependents 77 scripts 2.0k downloads

SOR - Estimation using Sequential Offsetted Regression

Estimation for longitudinal data following outcome dependent sampling using the sequential offsetted regression technique. Includes support for binary, count, and continuous data. The first regression is a logistic regression, which uses a known ratio (the probability of being sampled given that the subject/observation was referred divided by the probability of being sampled given that the subject/observation was no referred) as an offset to estimate the probability of being referred given outcome and covariates. The second regression uses this estimated probability to calculate the mean population response given covariates.

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1.70 score 2 scripts 157 downloads

titeIR - Isotonic Designs for Phase 1 Trials with Late-Onset Toxicities

Functions to design phase 1 trials using an isotonic regression based design incorporating time-to-event information. Simulation and design functions are available, which incorporate information about followup and DLTs, and apply isotonic regression to devise estimates of DLT probability.

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1.00 score 2 scripts 125 downloads